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Tuberculosis (TB)

Writer's picture: Ocen Chris Ocen Chris

TB is caused by bacteria (Mycobacterium tuberculosis) and it most often affects the lungs.


TB is spread through the air when people with lung TB cough, sneeze or spit. A person needs to inhale only a few germs to become infected.


Every year, 10 million people fall ill with tuberculosis (TB). Despite being a preventable and curable disease, 1.5 million people die from TB each year – making it the world’s top infectious killer.


TB is the leading cause of death of people with HIV and also a major contributor to antimicrobial resistance Tuberculosis (TB).


Despite advancements in medicine, TB remains a major global health concern, in both low-income earner and developing countries.


Causes and Transmission

TB spreads through the air when an infected person coughs, sneezes, or talks. The bacteria can remain in the air for hours, increasing the risk of infection for those nearby. However, not everyone exposed to TB bacteria becomes sick.


There are two forms of TB:

  1. Latent TB – The bacteria remain in the body without causing symptoms. The person is not contagious but may develop active TB later.


  2. Active TB – The bacteria multiply, causing symptoms and making the person contagious.


How can you identify a person with TB?

Here are some of the keys of some signs and symptoms if you have tuberculosis (TB).


However, if you feel any of the below condition, please seek medical care.

  • A cough that lasts more than 3 weeks – you may cough up mucus (phlegm) or mucus with blood in it.

  • Feeling tired or exhausted.

  • A high temperature or night sweats.

  • Loss of appetite.

  • Weight loss.

  • Feeling generally unwell. 

 

Risk factors

You have a higher risk of being exposed to TB germs if you:

  • Where born in or frequently travel to countries where TB is common, including some countries in Asia, Africa and Latin America.

  • Live or used to live in large group settings where TB is more common, such as homeless shelters, prison or jail.

  • Recently spent time with someone who has active TB disease.

  • Work in places where TB is more likely to spread.

  • You may have been exposed to TB germs if you spent time near someone with active TB disease.

 

NB !!! you have a higher risk of developing active TB disease once infected if you:

  • Were recently infected with TB germs.

  • Have a weaker immune system because of certain medications or health conditions such as debates, cancer and HIV.

  • Some people develop active TB disease soon (within weeks) after becoming infected, before their immune system can fight the TB germs. other people may get sick years later, when their immune system becomes weak for another reason.

 

Diagnosis and Treatment

TB is diagnosed using skin tests, blood tests, chest X-rays, and sputum tests. Early diagnosis is crucial for effective treatment and preventing the spread of the disease.


Treatment involves a combination of antibiotics taken for at least six months. The most common medications include:

  • Isoniazid

  • Rifampin

  • Ethambutol

  • Pyrazinamide


NB! Failure to complete the full course of treatment can lead to drug-resistant TB, which is more difficult to treat.


Prevention and Control

Preventing TB requires a combination of medical and public health strategies, including:

  • BCG Vaccine – Given to infants in countries with high TB prevalence, offering some protection.

  • Early Detection and Treatment – Identifying and treating TB early prevents its spread.

  • Proper Hygiene – Covering the mouth while coughing and ensuring good ventilation in living spaces reduces transmission.

  • Regular Screening – High-risk groups, such as healthcare workers and people with weakened immune systems, should undergo routine testing.


Conclusion

TB remains a serious health issue worldwide, particularly in regions with inadequate healthcare systems.


Efforts to enhance awareness, improve treatment accessibility, and promote preventive measures are essential in combating TB.


With global cooperation and medical advancements, the goal of eradicating TB can become a reality.


IMPORTANT NOTES

It important to take your antibiotics correctly and until you have completed the course, even if you feel better. If you stop your treatment early, TB could come back.

 

Literature of TB.

  1.  World Health Organization. Definitions and reporting framework for tuberculosis: 2013 revision (updated December 2014). Geneva: World Health Organization (2013).

  2. Islam MS., et al. “Prevalence of Tuberculosis: Present Status and Overview of Its Control System in Bangladesh”. International Journal of Life-Sciences Scientific Research 3.6 (2017): 1471- 1475.

  3. http://www.who.int/tb/publications/global_report/gtbr15_ main_text.pdf

  4.  Dolin GL., et al. Mandell, Douglas, and Bennett’s. Principles and Practice of Infectious Diseases. 7th ed., Philadelphia, PA; Churchill Livingstone (2011): 250-300.

  5. Campbell IA and Bah-Sow O. “Pulmonary tuberculosis: diagnosis and treatment”. British Medical Journal 332.7551 (2006): 1194-1197.

  6. Gupta B K., et al. “Role of Cerebrospinal fluid Adenosine deaminase levels estimation in diagnosis of tuberculous meningitis”. JIMA 111 (2013): 603-608.

  7. Vinay Bharat., et al. “Pleural fluid Adenosine deaminase activity- Can it be a diagnostic biomarker?” IOSR Journal of Dental and Medical Sciences 5 (2013): 41-46.

  8. Gahlot G., et al. “A Correlation of Adenosine Deaminase (ADA) Activity and Lipid Peroxidant (MDA) in Serum and Pleural Fluid for Diagnosis of Pulmonary Tuberculosis”. International Journal of Life-Sciences Scientific Research 3.3 (2017): 1063-1069.

  9. Sunita Singh., et al. “Primary Renal Tuberculosis Presented as Giant Cyst at Lower Pole of Kidney”. International Journal of Life-Sciences Scientific Research 3.4 (2017): 1148-1150.

  10. Prabhu SR., et al. “Tuberculosis ulcer of the tongue: Report of case”. Journal of Oral Surgery 36 (1978): 384-386.

  11. Kamala R., et al. “Primary tuberculosis of the oral cavity”. Indian Journal of Dental Research 22 (2011): 835-838.

  12.  Khammissa RAG., et al. “Primary Oral Tuberculosis as an Indicator of HIV Infection”. Pathology Research International (2011): 1-4.

  13. Wood NH., et al. “Tuberculosis part 1: pathophysiology and clinical manifestation”. South African Dental Association Journal 64.6 (2011): 270-273.

  14. Tarannum Yasmin and Krishan Nandan. “Correlation of Pulmonary Tuberculosis in HIV Positive Patients and its Association with CD4 Count”. International Journal of Life-Sciences Scientific Research 2.6 (2016): 733-736.

  15. WHO Tuberculosis Report (2017).

  16. Kolokotronis A., et al. “Oral tuberculosis”. Oral Disease 2 (1996): 242-243.

  17. Sharma SK and Mohan A. “Extrapulmonary tuberculosis”. Indian Journal of Medical Research 120 (2004): 316-353.

 

 

Author: Bongo Charles

Laboratory technician

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